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Article

Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients.

PloS one - 1 Jan 2017

Heng Jianfu, Guo Xinwu, Wu Wenhan, Wang Yue, Li Guoli, Chen Ming, Peng Limin, Wang Shouman, Dai Lizhong, Tang Lili, Wang Jun

Abstract excerpt

BACKGROUND: As downstream mediators of PI3K /PTEN /AKT /mTORC1 pathway, the AKT isoforms play critical roles in tumorgenesis. Although the pleiotropic effects of AKT1 in breast cancer have been reported, the genetic and epigenetic characteristics of AKT1 promoter region in breast cancer remains to be identified. In this study we aimed to investigate the promoter mutation spectrum, methylation and gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28301567
DOI: 10.1371/journal.pone.0174022
PMCID: PMC5354459

Genes

AKT1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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