Article
Combination of liquid crystal and deep learning reveals distinct signatures of Parkinson's disease-related wild-type α-synuclein and six pathogenic mutants.
Chemistry, an Asian journal - 17 Jan 2022
Yang Xiuxiu, Zhao Xiaofang, Zhao Hansen, Liu Fengwei, Zhang Sichun, Zhang Claire Xi, Yang Zhongqiang
Abstract excerpt
α-Synuclein is a central player in Parkinson's disease (PD) pathology. Various point mutations in α-synuclein have been identified to alter the protein-phospholipid binding behavior and cause PD. Therefore, exploration of α-synuclein-phospholipid interaction is important for understanding the PD pathogenesis and helping the early diagnosis of PD. Herein, a phospholipid-decorated liquid crystal (LC)-aqueous...
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