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Article

A Structural Proteomics Exploration of Synphilin-1 and Alpha-Synuclein Interaction in Pathogenesis of Parkinson's Disease.

Biomolecules - 12 Dec 2024

Tripathi Asmita, Mondal Rajkrishna, Mandal Malay, Lahiri Tapobrata, Pal Manoj Kumar

Abstract excerpt

Pathological significance of interaction of Synphilin-1 with mutated alpha-synuclein is well known to have serious consequences in causing the formation of inclusion bodies that are linked to Parkinson's disease (PD). Information extracted so far pointed out that specific mutations, A53T, A30P, and E46K, in alpha-synuclein promote such interactions. However, a detailed structural study of this interaction is...

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PMID: 39766295
DOI: 10.3390/biom14121588
PMCID: PMC11674031

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