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Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals.

Human molecular genetics - 15 Oct 2015

Shin Jean, Bourdon Celine, Bernard Manon, Wilson Michael D, Reischl Eva, Waldenberger Melanie, Ruggeri Barbara, Schumann Gunter, Desrivieres Sylvane, Leemans Alexander, Abrahamowicz Michal, Leonard Gabriel, Richer Louis, Bouchard Luigi, Gaudet Daniel, Paus Tomas, Pausova Zdenka

Abstract excerpt

DNA methylation may contribute to the etiology of complex genetic disorders through its impact on genome integrity and gene expression; it is modulated by DNA-sequence variants, named methylation quantitative trait loci (meQTLs). Most meQTLs influence methylation of a few CpG dinucleotides within short genomic regions (<3 kb). Here, we identified a layered genetic control of DNA methylation at numerous CpGs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26220975
DOI: 10.1093/hmg/ddv294
PMCID: PMC4581603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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