Interplay between genetic and environmental risk factors in multiple sclerosis: what have we learned?

Abstract excerpt

Genome-wide association studies have identified >230 genetic variants associated with susceptibility to multiple sclerosis and one genome-wide significant variant associated with progression of multiple sclerosis. Environmental risk factors, such as vitamin D deficiency and obesity, have also been implicated in multiple sclerosis pathogenesis. Statistical approaches building on these genetic data, such as...

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• Environment
• Epigenesis, Genetic
• Gene-Environment Interaction
• Genetic Predisposition to Disease
• Genome-Wide Association Study