Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length.

Abstract excerpt

Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational modification of the ribosome to be identified and is a commonly-used readout for mTORC1 activity. Although the cellular and organismal functions of RPS6 phosphorylation are known, the molecular consequences of RPS6 phosphorylation on translation are less well understood. Here we use selective ribosome footprinting to analyze the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HeLa Cells
• Share to Immunoblotting
• Share to Mechanistic Target of Rapamycin Complex 1