Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective translational control of cellular and viral mRNAs by RPS3 mRNA binding

18 Apr 2023

Abstract excerpt

RPS3, a universal core component of the 40S ribosomal subunit, interacts with mRNA at the entry channel. Whether RPS3 mRNA-binding contributes to specific mRNA translation and ribosome specialization in mammalian cells is unknown. Here we mutated RPS3 mRNA-contacting residues R116, R146 and K148 and report their impact on cellular and viral translation. R116D weakened cap-proximal initiation and promoted leaky...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to Viral Infections and Immunology Research
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37070189
DOI: 10.1093/nar/gkad269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective translational control of cellular and viral mRNAs by RPS3 mRNA bindingPMID 37070189Read ↗

Leaky scanning translates a conserved ORF in the 3′UTR of RPL36A and regulates the expression of ribosomal protein L36a.Semantic proximity Read ↗

Decoding regulatory specificity of human ribosomal proteinsSemantic proximity Read ↗

Translational Control of COVID-19 and Its Therapeutic ImplicationSemantic proximity Read ↗

Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length.Semantic proximity Read ↗

Biological Significance and Therapeutic Promise of Programmed Ribosomal FrameshiftingSemantic proximity Read ↗

The differential effect of SARS-CoV-2 NSP1 on mRNA translation and stability reveals new insights linking ribosome recruitment, codon usage, and virus evolutionSemantic proximity Read ↗

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.Semantic proximity Read ↗

IRES Trans-Acting Factors, Key Actors of the Stress ResponseSemantic proximity Read ↗

Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral responseSemantic proximity Read ↗

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read ↗

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons.Semantic proximity Read ↗

Genes with 5′ terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 Nsp1 proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.