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Coronavirus genomic nsp14‐ExoN, structure, role, mechanism, and potential application as a drug target

10 Apr 2021

Abstract excerpt

The recent coronavirus disease 2019 (COVID-19), causing a global pandemic with devastating effects on healthcare and social-economic systems, has no special antiviral therapies available for human coronaviruses (CoVs). The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) possesses a nonstructural protein (nsp14), with amino-terminal domain coding for proofreading exoribonuclease (ExoN) that is...

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PMID: 33837972
DOI: 10.1002/jmv.27009

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