Article
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
mBio - 6 Mar 2018
Agostini Maria L, Andres Erica L, Sims Amy C, Graham Rachel L, Sheahan Timothy P, Lu Xiaotao, Smith Everett Clinton, Case James Brett, Feng Joy Y, Jordan Robert, Ray Adrian S, Cihlar Tomas, Siegel Dustin, Mackman Richard L, Clarke Michael O, Baric Ralph S, Denison Mark R
Abstract excerpt
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity. We recently reported that the nucleoside analogue GS-5734 (remdesivir) potently inhibits human and zoonotic CoVs in vitro and in a severe acute respiratory syndrome coronavirus...
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