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Article

Identification of recurrent mutations in exonuclease (nsp14); a potential drug target in SARS-CoV-2.

Indian journal of pathology & microbiology - 1 Jan 2000

Jha Deepak Kumar, Yashvardhini Niti, Kumar Amit

Abstract excerpt

CONTEXT: The rapid outbreak of SARS-CoV-2 has become a significant global health concern, highlighting the dire need for antiviral therapeutic agents. RNA-dependent RNA polymerase (RdRp) of coronavirus plays crucial roles in RNA synthesis, and hence remains the druggable target for the treatment of this disease. The most potent broad-spectrum inhibitors of viral RdRp are members of nucleoside analogs (NAs)....

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PMID: 34673601
DOI: 10.4103/0377-4929.328516

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