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Article

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.

The EMBO journal - 17 Mar 2003

Lufei Chengchen, Ma Jing, Huang Guochang, Zhang Tong, Novotny-Diermayr Veronica, Ong Chin Thing, Cao Xinmin

Abstract excerpt

Signal transducer and activator of transcription 3 (Stat3) is a latent cytoplasmic transcription factor that can be activated by cytokines and growth factors. Stat3 plays important roles in cell growth, anti-apoptosis and cell transformation, and is constitutively active in various cancers. We examined its potential regulators by yeast two-hybrid screening. GRIM-19, a gene product related to interferon-beta- and...

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Identifiers

PMID: 12628925
DOI: 10.1093/emboj/cdg135
PMCID: PMC151078

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.PMID 12628925Read ↗

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