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Article

Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology.

Journal of molecular biology - 21 Aug 2020

Goblirsch Brandon R, Wiener Michael C

Abstract excerpt

Ste24, an integral membrane protein zinc metalloprotease, is found in every kingdom of eukaryotes. It was discovered approximately 20 years ago by yeast genetic screens identifying it as a factor responsible for processing the yeast mating a-factor pheromone. In animals, Ste24 processes prelamin A, a component of the nuclear lamina; mutations in the human ortholog of Ste24 diminish its activity, giving rise to...

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Identifiers

PMID: 32199981
DOI: 10.1016/j.jmb.2020.03.016
PMCID: PMC7172729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology.PMID 32199981Read ↗

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