Article
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Cell - 4 Oct 2002
Ma Yong, Erkner Alfrun, Gong Ruoyu, Yao Shenqin, Taipale Jussi, Basler Konrad, Beachy Philip A
Abstract excerpt
The dispatched (disp) gene is required for long-range Hedgehog (Hh) signaling in Drosophila. Here, we demonstrate that one of two murine homologs, mDispA, can rescue disp function in Drosophila and is essential for all Hh patterning activities examined in the early mouse embryo. Embryonic fibrobl...
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