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Article

Disp1 regulates growth of mammalian long bones through the control of Ihh distribution.

Developmental biology - 15 May 2008

Tsiairis Charisios D, McMahon Andrew P

Abstract excerpt

Dispatched1 (Disp1) is required for the release of cholesterol modified hedgehog (Hh) proteins from producing cells. We investigated the role of Disp1 in Indian hedgehog (Ihh) signaling in the developing bone bypassing the lethality of the Disp1(C829F) allele at early somite stages through the supply of non-cholesterol modified Sonic hedgehog (N-Shh). The long bones that develop in the absence of wild-type Disp1,...

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Identifiers

PMID: 18395198
DOI: 10.1016/j.ydbio.2008.02.039
PMCID: PMC2430380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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