Article
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.
Development (Cambridge, England) - 1 Dec 2002
Kawakami Takatoshi, Kawcak T'Nay, Li Ya-Jun, Zhang Wanhui, Hu Yongmei, Chuang Pao-Tien
Abstract excerpt
Hedgehog (Hh) signaling plays a major role in multiple aspects of embryonic development, which involves both short- and long-range signaling from localized Hh sources. One unusual aspect of Hh signaling is the autoproteolytic processing of Hh followed by lipid modification. As a consequence, the N-terminal fragment of Hh becomes membrane anchored on the cell surface of Hh-producing cells. A key issue in Hh...
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