Article
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia.
Experimental biology and medicine (Maywood, N.J.) - 1 Apr 2022
Raballah Evans, Anyona Samuel B, Cheng Qiuying, Munde Elly O, Hurwitz Ivy-Foo, Onyango Clinton, Ndege Caroline, Hengartner Nicolas W, Pacheco Maria Andreína, Escalante Ananias A, Lambert Christophe G, Ouma Collins, Obama Henri C Jr T, Schneider Kristan A, Seidenberg Philip D, McMahon Benjamin H, Perkins Douglas J
Abstract excerpt
Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored the relationship between complement component 3 (C3) missense mutations [rs2230199 (2307C>G, Arg>Gly102) and rs11569534 (34420G>A, Gly>Asp1224)], malaria, and SMA in a cohort of children (n = 1617...
Read the complete abstract on PubMed