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Article

Impact of age, HIV1, sickle-cell genotypes, and interferon-gamma gene upstream variants on malaria disease outcomes in a longitudinal pediatric cohort.

Scientific reports - 16 Apr 2025

Raballah Evans, Anyona Samuel B, Osata Shamim W, Wasena Sharley A, Onyango Clinton, Hurwitz Ivy, Cheng Qiuying, Seidenberg Philip D, McMahon Benjamin H, Ouma Collins, Ong'echa John M, Schneider Kristan A, Perkins Douglas J

Abstract excerpt

This prospective cohort study explored the association between two upstream IFN-γ variants (rs2069709: G > T and rs2069705: A > G) and hazard factors for malaria outcomes in a longitudinal cohort of children (n = 941, 3-36 mos.), followed for three years. The impact of age, sex, previous malaria exposure, HIV1 infection, and sickle-cell genotypes (HbAA, HbAS, and HbSS) was also investigated. Reduced malaria...

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Identifiers

PMID: 40234522
DOI: 10.1038/s41598-025-97267-x
PMCID: PMC12000329

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