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Article

Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia.

BMC genomics - 13 Sept 2023

Onyango Clinton O, Cheng Qiuying, Munde Elly O, Raballah Evans, Anyona Samuel B, McMahon Benjamin H, Lambert Christophe G, Onyango Patrick O, Schneider Kristan A, Perkins Douglas J, Ouma Collins

Abstract excerpt

BACKGROUND: Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common clinical manifestation of severe malaria in such regions. Although innate immune response genes are known to influence the development of SMA, the role of natural killer (NK) cells in malaria...

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Identifiers

PMID: 37704951
DOI: 10.1186/s12864-023-09565-1
PMCID: PMC10498606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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