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Article

Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast.

Viruses - 10 Nov 2021

Rossi Átila Duque, Faucz Fabio Rueda, Melo Adriana, de Azevedo Girlene Souza, Pezzuto Paula, Bezerra Ohanna Cavalcanti de Lima, Manta Fernanda Saloum de Neves, Azamor Tamiris, Schamber-Reis Bruno Luiz Fonseca, Tanuri Amilcar, Moraes Milton Ozório, Aguiar Renato Santana, Stratakis Constantine A, Cardoso Cynthia Chester

Abstract excerpt

Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However,...

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Identifiers

PMID: 34835060
DOI: 10.3390/v13112253
PMCID: PMC8622836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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