Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly.

doi:10.1038/s41598-023-30342-3

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Article

Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly.

Scientific reports - 1 Mar 2023

Santos Camilla Natália Oliveira, Magalhães Lucas Sousa, Fonseca Adriana Barbosa de Lima, Bispo Ana Jovina Barreto, Porto Roseane Lima Santos, Alves Juliana Cardoso, Dos Santos Cliomar Alves, de Carvalho Jaira Vanessa, da Silva Angela Maria, Teixeira Mauro Martins, de Almeida Roque Pacheco, Dos Santos Priscila Lima, de Jesus Amélia Ribeiro

Abstract excerpt

Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological and environmental factors, the genetic host factors are suggested as important to the CZS occurrence and development, however, few studies have evaluated this. This study enrolled a total of 245...

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PMID: 36859461
DOI: 10.1038/s41598-023-30342-3
PMCID: PMC9975867

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