Article
Association between Genetic Variants in NOS2 and TNF Genes with Congenital Zika Syndrome and Severe Microcephaly.
Viruses - 20 Feb 2021
Gomes Julia A, Sgarioni Eduarda, Boquett Juliano A, Terças-Trettel Ana Cláudia P, da Silva Juliana H, Ribeiro Bethânia F R, Galera Marcial F, de Oliveira Thalita M, Carvalho de Andrade Maria Denise F, Carvalho Isabella F, Schüler-Faccini Lavínia, Vianna Fernanda S L
Abstract excerpt
Zika virus (ZIKV) causes Congenital Zika Syndrome (CZS) in individuals exposed prenatally. Here, we investigated polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes as risk factors to CZS. Forty children with CZS and forty-eight children who were in utero exposed to ZIKV infection, but born without congenital anomalies, were evaluated. Children with CZS were predominantly infected by ZIKV in the first...
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