Article
Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis.
Frontiers in cellular and infection microbiology - 1 Jan 2021
Gomes Julia A, Sgarioni Eduarda, Vieira Igor A, Fraga Lucas R, Ashton-Prolla Patrícia, Terças-Tretell Ana Cláudia P, da Silva Juliana H, Ribeiro Bethânia F R, Galera Marcial F, de Oliveira Thalita M, Carvalho de Andrade Maria Denise F, Carvalho Isabella F, Schuler-Faccini Lavínia, Vianna Fernanda S L
Abstract excerpt
Congenital Zika Syndrome (CZS) occurs in up to 42% of individuals exposed to ZIKV prenatally. Deregulation in gene expression and protein levels of components of the p53 signaling pathway, such as p53 and MDM2, due to ZIKV infection has been reported. Here, we evaluate functional polymorphisms in genes of the p53 signaling pathway as risk factors to CZS. Forty children born with CZS and forty-eight children...
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