Article
NPAS3 variants in schizophrenia: a neuroimaging study.
BMC medical genetics - 27 Mar 2014
Bernier Denise, Macintyre Georgina, Bartha Robert, Hanstock Christopher C, McAllindon David, Cox Diane, Purdon Scot, Aitchison Katherine J, Rusak Benjamin, Tibbo Philip G
Abstract excerpt
BACKGROUND: This research is a one-site neuroimaging component of a two-site genetic study involving patients with schizophrenia at early and later stages of illness. Studies support a role for the neuronal Per-Arnt-Sim 3 (NPAS3) gene in processes that are essential for normal brain development. Specific NPAS3 variants have been observed at an increased frequency in schizophrenia. In humans, NPAS3 protein was...
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