Article
Comparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles.
Translational psychiatry - 9 Nov 2022
Oraki Kohshour Mojtaba, Kannaiyan Nirmal R, Falk August Jernbom, Papiol Sergi, Heilbronner Urs, Budde Monika, Kalman Janos L, Schulte Eva C, Rietschel Marcella, Witt Stephanie, Forstner Andreas J, Heilmann-Heimbach Stefanie, Nöthen Markus M, Spitzer Carsten, Malchow Berend, Müller Thorsten, Wiltfang Jens, Falkai Peter, Schmitt Andrea, Rossner Moritz J, Nilsson Peter, Schulze Thomas G
Abstract excerpt
The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to serum samples of healthy controls and individuals with SCZ and BD with the aim of identifying differentially expressed proteins in these disorders. Moreover, we explored the influence of polygenic burden for SCZ...
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