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Article

Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.

Biological psychiatry - 1 Aug 2017

Michaelson Jacob J, Shin Min-Kyoo, Koh Jin-Young, Brueggeman Leo, Zhang Angela, Katzman Aaron, McDaniel Latisha, Fang Mimi, Pufall Miles, Pieper Andrew A

Abstract excerpt

BACKGROUND: NPAS3 has been established as a robust genetic risk factor in major mental illness. In mice, loss of neuronal PAS domain protein 3 (NPAS3) impairs postnatal hippocampal neurogenesis, while loss of the related protein NPAS1 promotes it. These and other findings suggest a critical role for NPAS proteins in neuropsychiatric functioning, prompting interest in the molecular pathways under their control....

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Identifiers

PMID: 28499489
DOI: 10.1016/j.biopsych.2017.03.021
PMCID: PMC6901278

Genes

NPAS1
NPAS3

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