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Article

Selectivity Determinants of RHO GTPase Binding to IQGAPs.

International journal of molecular sciences - 22 Nov 2021

Mosaddeghzadeh Niloufar, Nouri Kazem, Krumbach Oliver H F, Amin Ehsan, Dvorsky Radovan, Ahmadian Mohammad R

Abstract excerpt

IQ motif-containing GTPase-activating proteins (IQGAPs) modulate a wide range of cellular processes by acting as scaffolds and driving protein components into distinct signaling networks. Their functional states have been proposed to be controlled by members of the RHO family of GTPases, among other regulators. In this study, we show that IQGAP1 and IQGAP2 can associate with CDC42 and RAC1-like proteins but not...

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Identifiers

PMID: 34830479
DOI: 10.3390/ijms222212596
PMCID: PMC8625570

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