Article
The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes.
The Journal of biological chemistry - 18 Jan 2008
Owen Darerca, Campbell Louise J, Littlefield Keily, Evetts Katrina A, Li Zhigang, Sacks David B, Lowe Peter N, Mott Helen R
Abstract excerpt
IQGAP1 contains a domain related to the catalytic portion of the GTPase-activating proteins (GAPs) for the Ras small G proteins, yet it has no RasGAP activity and binds to the Rho family small G proteins Cdc42 and Rac1. It is thought that IQGAP1 is an effector of Rac1 and Cdc42, regulating cell-cell adhesion through the E-cadherin-catenin complex, which controls formation and maintenance of adherens junctions....
Topics
- Amino Acid Sequence
- Binding Sites
- GTPase-Activating Proteins
- Guanosine Triphosphate
- Models, Molecular
- Molecular Sequence Data
- Mutant Proteins
- Mutation
- Protein Binding
- Protein Structure, Tertiary