Deciphering the Molecular and Functional Basis of Dbl Family Proteins

Abstract excerpt

The diffuse B-cell lymphoma (Dbl) family of the guanine nucleotide exchange factors is a direct activator of the Rho family proteins. The Rho family proteins are involved in almost every cellular process that ranges from fundamental ( e.g. the establishment of cell polarity) to highly specialized processes ( e.g. the contraction of vascular smooth muscle cells). Abnormal activation of the Rho proteins is known to...

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