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Article

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.

Molecular systems biology - 21 Jun 2011

Alic Nazif, Andrews T Daniel, Giannakou Maria E, Papatheodorou Irene, Slack Cathy, Hoddinott Matthew P, Cochemé Helena M, Schuster Eugene F, Thornton Janet M, Partridge Linda

Abstract excerpt

FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcription of several IIS components and interacting pathways, such as TOR, in the wild-type fly. The genomic locations...

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Identifiers

PMID: 21694719
DOI: 10.1038/msb.2011.36
PMCID: PMC3159968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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