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The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

21 Dec 2020

Abstract excerpt

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses circulating in bats, SARS-CoV-2 is thought to have originated in Chiroptera species in China. However, whether the virus spread directly to humans or...

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PMID: 33347434
DOI: 10.1371/journal.pbio.3001016

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