Article

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients

2021-08-17

Abstract excerpt

RaTG13 is a close relative of SARS-CoV-2, the virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, sharing 96% sequence similarity at the genome-wide level. The spike receptor binding domain (RBD) of RaTG13 contains a large number of amino acid substitutions when compared to SARS-CoV-2, likely impacting affinity for the ACE2 receptor. Antigenic differences between the viruses are less well under...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd3bdec8-c074-5ef6-95d2-b7d9e14e831d
DOI: 10.1101/2021.08.17.456606

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected PatientsDOI 10.1101/2021.08.17.456606Read

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patientsSemantic proximity Read

Spike residue 403 affects binding of coronavirus spikes to human ACE2.Semantic proximity Read

Understanding the future risk of bat coronavirus spillover into humans – correlating sarbecovirus receptor usage, host range, and antigenicitySemantic proximity Read

Cross-Neutralizing Monoclonal Antibodies with Broad Activity Against Human and Bat-Derived SARS-Related CoronavirusesSemantic proximity Read

Structural and functional dissection of neutralisation differences among SARS-CoV-2 variants using antigenicity prediction and CR3022 binding analysis.Semantic proximity Read

Risk assessment of SARS-CoV-2 replicating and evolving in animals.Semantic proximity Read

Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to humanSemantic proximity Read

Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native and B.1.351 SARS-CoV-2 spike proteinsSemantic proximity Read

Human neutralising antibodies elicited by SARS‐CoV‐2 non‐D614G variants offer cross‐protection against the SARS‐CoV‐2 D614G variantSemantic proximity Read

Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike proteinSemantic proximity Read

Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity.Semantic proximity Read

Recurrent Emergence and Transmission of a SARS-CoV-2 Spike Deletion H69/V70Semantic proximity Read