Article

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

2021-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, most likely emerged from bats 1 . A prerequisite for this devastating zoonosis was the ability of the SARS-CoV-2 Spike (S) glycoprotein to use human angiotensin-converting enzyme 2 (ACE2) for viral entry. Although the S protein of the closest related bat virus, RaTG13, shows high similarity to the...

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Literature Corpus work: 5d9abff5-5448-5283-9318-26a1338218c0
DOI: 10.1101/2021.05.31.446386

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