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Article

H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility.

American journal of human genetics - 2 Dec 2021

Giambartolomei Claudia, Seo Ji-Heui, Schwarz Tommer, Freund Malika Kumar, Johnson Ruth Dolly, Spisak Sandor, Baca Sylvan C, Gusev Alexander, Mancuso Nicholas, Pasaniuc Bogdan, Freedman Matthew L

Abstract excerpt

Genome-wide association studies (GWASs) have identified more than 200 prostate cancer (PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines of evidence show that a significant proportion of PrCa risk can be explained by germline causal variants that dysregulate nearby target genes in prostate-relevant tissues, thus altering disease risk. The traditional approach to explore...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34822763
DOI: 10.1016/j.ajhg.2021.11.007
PMCID: PMC8715276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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