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Article

Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer.

British journal of cancer - 28 Mar 2017

Jones Robert P, Sutton Paul A, Evans Jonathan P, Clifford Rachel, McAvoy Andrew, Lewis James, Rousseau Abigail, Mountford Roger, McWhirter Derek, Malik Hassan Z

Abstract excerpt

BACKGROUND: Activating mutations in KRAS have been suggested as potential predictive and prognostic biomarkers. However, the prognostic impact of specific point mutations remains less clear. This study assessed the prognostic impact of specific KRAS mutations on survival for patients with colorectal cancer. METHODS: Retrospective review of patients KRAS typed for advanced and recurrent colorectal cancer between...

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Source

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Identifiers

PMID: 28208157
DOI: 10.1038/bjc.2017.37
PMCID: PMC5379149

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer.PMID 28208157Read ↗

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