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Article

Prevalence of RAS mutations and individual variation patterns among patients with metastatic colorectal cancer: A pooled analysis of randomised controlled trials.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2015

Peeters M, Kafatos G, Taylor A, Gastanaga V M, Oliner K S, Hechmati G, Terwey J-H, van Krieken J H

Abstract excerpt

BACKGROUND: The use of epidermal growth factor receptor inhibitors to treat metastatic colorectal cancer (mCRC) patients requires prior confirmation of tumour wild type (WT) RAS mutation status (exons 2/3/4 for KRAS or NRAS). This retrospective pooled analysis aims to robustly estimate RAS mutati...

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Source

Identifiers

PMID: 26049686
DOI: 10.1016/j.ejca.2015.05.017

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26049686-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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