Article
KRAS G12C Metastatic Colorectal Cancer: Specific Features of a New Emerging Target Population.
Clinical colorectal cancer - 1 Sept 2020
Schirripa Marta, Nappo Floriana, Cremolini Chiara, Salvatore Lisa, Rossini Daniele, Bensi Maria, Businello Gianluca, Pietrantonio Filippo, Randon Giovanni, Fucà Giovanni, Boccaccino Alessandra, Bergamo Francesca, Lonardi Sara, Dei Tos Angelo Paolo, Fassan Matteo, Loupakis Fotios
Abstract excerpt
BACKGROUND: Kirsten rat sarcoma viral oncogene (KRAS) G12C mutation occurs in about 4% of colorectal cancers (CRCs). Recently, KRAS G12C was identified to be a potential drug target and predictor of response to the novel on AMG510 target treatment. We described the clinicopathologic features and prognosis of KRAS G12C-mutated metastatic CRCs compared to other KRAS mutation. PATIENTS AND METHODS: Clinicopathologic...
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