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Article

Mutations matter: An observational study of the prognostic and predictive value of KRAS mutations in metastatic colorectal cancer

29 Nov 2022

Abstract excerpt

Background: About half of metastatic colorectal cancers (CRCs) harbor Rat Sarcoma (RAS) activating mutations as oncogenic driver, but the prognostic role of RAS mutations is not fully elucidated. Interestingly, specific hotspot mutations have been identified as potential candidates for novel targeted therapies in several malignancies as per G12C. This study aims at evaluating the association between KRAS hotspot...

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Identifiers

PMID: 36523988
DOI: 10.3389/fonc.2022.1055019

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