Article
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes.
Genetics and molecular research : GMR - 16 Feb 2017
Zekri J, Al-Shehri A, Mahrous M, Al-Rehaily S, Darwish T, Bassi S, El Taani H, Al Zahrani A, Elsamany S, Al-Maghrabi J, Sadiq B B
Abstract excerpt
Mutations in codons 12/13 of K-ras exon 2 are associated with reduced benefit from anti-epidermal growth factor receptor antibody treatment for metastatic colorectal cancer (CRC). Here, we evaluated the frequency of K-ras mutations and their relationship with clinicopathological features and treatment outcomes in Saudi Arabian patients with CRC. The genetic status of K-ras was determined in 300 patients diagnosed...
Topics
- Adult
- Aged
- Aged, 80 and over
- Arabs
- Colorectal Neoplasms
- Exons
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Mutation Rate
- Prognosis
- Proto-Oncogene Proteins p21(ras)