Article

Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient Mutants

2024-11-27

Abstract excerpt

The obligate intracellular parasite Toxoplasma gondii replicates within a specialized compartment called the parasitophorous vacuole (PV). Recent work showed that despite living within a PV, Toxoplasma endocytoses proteins from the cytosol of infected host cells via a so-called ingestion pathway. The ingestion pathway is initiated by dense granule protein GRA14, which binds host ESCRT machinery to bud vesicles i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea5431fd-4525-580f-be39-43a671ec02cc
DOI: 10.1101/2024.11.27.625683

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient MutantsDOI 10.1101/2024.11.27.625683Read

Metabolic adaptability and nutrient scavenging in Toxoplasma gondii: insights from ingestion pathway-deficient mutants.Semantic proximity Read

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.Semantic proximity Read

Synthesis vs. salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondiiSemantic proximity Read

Vitamin and cofactor acquisition in apicomplexans: Synthesis versus salvageSemantic proximity Read

Toxoplasma gondii Fatty Acid Elongases are Important for Virulence and PersistenceSemantic proximity Read

Phosphatidylethanolamine Synthesis in the Parasite Mitochondrion Is Required for Efficient Growth but Dispensable for Survival of Toxoplasma gondiiSemantic proximity Read

Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii.Semantic proximity Read

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.Semantic proximity Read

An ortholog of P. falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasionSemantic proximity Read

Synthesis versus Salvage of Ester- and Ether-linked Phosphatidylethanolamine in the Intracellular Protozoan Pathogen Toxoplasma gondiiSemantic proximity Read

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoitesSemantic proximity Read

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cystsSemantic proximity Read