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Article

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Cell - 30 Jul 2015

Birsoy Kıvanç, Wang Tim, Chen Walter W, Freinkman Elizaveta, Abu-Remaileh Monther, Sabatini David M

Abstract excerpt

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also not well understood why pyruvate supplementation allows cells lacking ETC function to proliferate. We used a CRISPR-based genetic screen to identify genes whose loss sensitizes human cells to phenformin, a complex I inhibitor. The screen yielded GOT1, the...

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Identifiers

PMID: 26232224
DOI: 10.1016/j.cell.2015.07.016
PMCID: PMC4522279

Genes

GOT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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