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Article

Emerging links among Chromosome Instability (CIN), cancer, and aging.

Molecular carcinogenesis - 1 Mar 2017

Rao Chinthalapally V, Asch Adam S, Yamada Hiroshi Y

Abstract excerpt

Aneuploidy was predicted to cause cancer. To test the prediction, various Chromosome Instability (CIN) mice models that carry transgenic mutations in mitotic regulators have been created. The availability of these mice has aided researchers in discovering connections between CIN, cancer, and aging. This review will focus on recent interdisciplinary findings regarding how CIN and aneuploidy affect carcinogenesis,...

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PMID: 27533343
DOI: 10.1002/mc.22539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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