Article
Why SNP rs3755955 is associated with human bone mineral density? A molecular and cellular study in bone cells.
Molecular and cellular biochemistry - 1 Feb 2022
He Pei, Jiang Fei, Wu Long-Fei, Zhou Xu, Lei Shu-Feng, Deng Fei-Yan
Abstract excerpt
SNP rs3755955 (major/minor allele: G/A) located in Iduronidase-Alpha-L- (IDUA) gene was reported to be significant for human bone mineral density (BMD). This follow-up study was to uncover the underlying association mechanism through molecular and cellular functional assays relevant to bone. We tested the effects of single nucleotide polymorphisms (SNP) rs3755955 (defined allele G as wild-type and allele A as...
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