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Unraveling the Mechanism of Impaired Osteogenic Differentiation in Osteoporosis: Insights from ADRB2 Gene Polymorphism.

Cells - 20 Dec 2024

Krasnova Olga, Sopova Julia, Kovaleva Anastasiia, Semenova Polina, Zhuk Anna, Smirnova Daria, Perepletchikova Daria, Bystrova Olga, Martynova Marina, Karelkin Vitaly, Lesnyak Olga, Neganova Irina

Abstract excerpt

Osteoporosis is characterized by increased resorption and decreased bone formation; it is predominantly influenced by genetic factors. G-protein coupled receptors (GPCRs) play a vital role in bone homeostasis, and mutations in these genes are associated with osteoporosis. This study aimed to investigate the impact of single nucleotide polymorphism (SNP) rs1042713 in the ADRB2 gene, encoding the beta-2-adrenergic...

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Cell Differentiation
Cell Proliferation
Mesenchymal Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Receptors, Adrenergic, beta-2

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PMID: 39768200
DOI: 10.3390/cells13242110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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