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Article

Chromothripsis followed by circular recombination drives oncogene amplification in human cancer.

Nature genetics - 1 Dec 2021

Rosswog Carolina, Bartenhagen Christoph, Welte Anne, Kahlert Yvonne, Hemstedt Nadine, Lorenz Witali, Cartolano Maria, Ackermann Sandra, Perner Sven, Vogel Wenzel, Altmüller Janine, Nürnberg Peter, Hertwig Falk, Göhring Gudrun, Lilienweiss Esther, Stütz Adrian M, Korbel Jan O, Thomas Roman K, Peifer Martin, Fischer Matthias

Abstract excerpt

The mechanisms behind the evolution of complex genomic amplifications in cancer have remained largely unclear. Using whole-genome sequencing data of the pediatric tumor neuroblastoma, we here identified a type of amplification, termed 'seismic amplification', that is characterized by multiple rearrangements and discontinuous copy number levels. Overall, seismic amplifications occurred in 9.9% (274 of 2,756) of...

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Identifiers

PMID: 34782764
DOI: 10.1038/s41588-021-00951-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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