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Structure–function relationship and biogenesis regulation of the human telomerase holoenzyme

3 Apr 2013

Abstract excerpt

Telomeres are nucleoprotein structures found at the ends of linear chromosomes. Telomeric DNA shortens with each cell division, effectively restricting the proliferative capacity of human cells. Telomerase, a specialized reverse transcriptase, is responsible for de novo synthesis of telomeric DNA, and is the major physiological means by which mammalian cells extend telomere length. Telomerase activity in human...

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PMID: 23551398
DOI: 10.1111/febs.12272

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