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Article

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.

Science (New York, N.Y.) - 10 Jul 2025

Balch Sebastian, Sekne Zala, Franco-Echevarría Elsa, Ludzia Patryk, Kretsch Rachael C, Sun Wenqing, Yu Haopeng, Ghanim George E, Thorkelsson Sigurdur, Ding Yiliang, Das Rhiju, Nguyen Thi Hoang Duong

Abstract excerpt

Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showed that human telomerase is typically monomeric, containing a single copy of TERT and hTR. Evidence for dimeric complexes exists, although the composition, high-resolution structure, and function remain elusive. Here,...

Read the complete abstract on PubMed

Topics

Humans
Cryoelectron Microscopy
DNA
Mutation
Protein Multimerization
RNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Telomerase

Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 40638752
DOI: 10.1126/science.adr5817
PMCID: PMC7618144

Genes

TERT

Provenance

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