Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.

doi:10.1038/s41380-021-01379-5

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Article

Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.

Molecular psychiatry - 1 Feb 2022

Thalamuthu Anbupalam, Mills Natalie T, Berger Klaus, Minnerup Heike, Grotegerd Dominik, Dannlowski Udo, Meinert Susanne, Opel Nils, Repple Jonathan, Gruber Marius, Nenadić Igor, Stein Frederike, Brosch Katharina, Meller Tina, Pfarr Julia-Katharina, Forstner Andreas J, Hoffmann Per, Nöthen Markus M, Witt Stephanie, Rietschel Marcella, Kircher Tilo, Adams Mark, McIntosh Andrew M, Porteous David J, Deary Ian J, Hayward Caroline, Campbell Archie, Grabe Hans Jörgen, Teumer Alexander, Homuth Georg, van der Auwera-Palitschka Sandra, Schubert K Oliver, Baune Bernhard T

Abstract excerpt

Major Depressive Disorder (MDD) often is associated with significant cognitive dysfunction. We conducted a meta-analysis of genome-wide interaction of MDD and cognitive function using data from four large European cohorts in a total of 3510 MDD cases and 6057 controls. In addition, we conducted analyses using polygenic risk scores (PRS) based on data from the Psychiatric Genomics Consortium (PGC) on the traits of...

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PMID: 34782712
DOI: 10.1038/s41380-021-01379-5
PMCID: PMC7612684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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