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Article

Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder.

Journal of affective disorders - 15 Mar 2020

Wang Xin, Cheng Weiqiu, Zhu Jin, Yin Hongtao, Chang Suhua, Yue Weihua, Yu Hao

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified several genetic variants associated with major depression disorder (MDD). However, pinpointing the causal variants which are responsible for the association signal at a risk locus remains a major challenge. METHODS: We used Summary data-based Mendelian Randomization (SMR) with Psychiatric Genomics Consortium (PGC) GWAS summary and brain expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32090785
DOI: 10.1016/j.jad.2019.11.116

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