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Article

Integrating Multi-Omics Summary Data Identifies Candidate Molecular Mechanisms for Major Depression.

Biological psychiatry - 15 Jun 2026

Nisbet Laurence, Wu Yang, Adams Mark, Lynall Mary-Ellen, Hjerling-Leffler Jens, Wray Naomi R, McIntosh Andrew M, Shen Xueyi

Abstract excerpt

BACKGROUND: Major depression (MD) is the most common psychiatric disorder. However, despite having a significant genetic component, the underlying biological mechanisms remain poorly understood. Our analyses leveraged molecular quantitative trait loci (xQTL) data to identify molecular biomarkers for MD. METHODS: We used OPERA (Omics Pleiotropic Association) software to identify molecular phenotypes associated...

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Source

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Identifiers

PMID: 41407005
DOI: 10.1016/j.biopsych.2025.11.024
PMCID: PMC13527628

Genes

CDH13
H6PD
RAB27B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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