Article
The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence.
British journal of cancer - 1 Jan 2021
Rabbie Roy, Ferguson Peter, Wong Kim, Couturier Dominique-Laurent, Moran Una, Turner Clinton, Emanuel Patrick, Haas Kerstin, Saunus Jodi M, Davidson Morgan R, Lakhani Sunil R, Shivalingam Brindha, Long Georgina V, Parkinson Christine, Osman Iman, Scolyer Richard A, Corrie Pippa, Adams David J
Abstract excerpt
Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing of 50 tumours from patients undergoing surgical resection of brain metastases presenting as the first site of visceral disease spread and validated our findings in an independent dataset of 18 patients. Brain metastases had a similar driver mutational landscape to cutaneous melanomas in TCGA....
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